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What is Adulteration?

Adulteration is the intentional tampering with a urine sample by the donor to avoid detection of illicit drug use. Successful adulteration produces a false-negative drug test result. Many techniques have been devised for this purpose, including:

• Eating or drinking substances that the donor believes will chemically alter drug test results.
• Adding substances (salt, vinegar, bleach, detergent, Drano, Visine, etc.) directly to the urine sample to chemically alter test results.
• Diluting the urine sample, e.g., by drinking large amounts of liquid, taking a diuretic to increase urination, or adding water directly to the specimen to lower the concentration of the drug so that it becomes undetectable by the test.
• Substituting the donor's specimen with someone else's drug-free urine.

How can I guard against adulteration when collecting samples?

Direct observation of the donor as he/she provides the sample is a foolproof way to prevent specimen substitution or the direct addition of foreign substances to the sample. However, direct observation is commonly considered an infringement of individual privacy and is rarely done, especially in pre-employment and other workplace testing.

There are, however, other preventive measures you should take:

• Federal guidelines suggest, for example, that donors not be permitted to wear coats or bulky clothing or carry purses when giving samples, that they present adequate identification before giving samples, and that sample temperature be immediately tested.
• The collection area, usually a restroom, can be secured by turning off the hot water tap, putting a coloring agent in the toilet bowl, and inspecting the area for concealed adulterants. Donors can be required to wash their hands just before giving a sample, hampering their ability to conceal adulterants in the palm of their hand or even under the fingernails.

Adulterants can be classified into two categories

Products to help guard against adulteration

STAT-BLUE

Toilet Blueing Solution. Eliminate the adulteration of urine sample by substituting toilet water for the urine sample. Easy to use! Flush toilet and when fresh water enters bowl, dispense one STAT-BLUE™ tablet. One tablet instantly turns the toilet bowl or tank water blue. There is no porcelain staining and blue color does not carry over after flushing.

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The iScreen Drug Adulteration Strips

The iScreen Drug Adulteration Strips are a fast dip-and-read test for the determination of diluted or adulterated urine specimens. They are an important prescreening test for any drug testing program.

The six-in one test strips are based on the chemical reactions of the indicator reagents on the pads with components in the urine sample effecting color changes.

• Creatinine-Testing the sample for dilution
• Glutaraldehyde-Testing for the presence of exogenous aldehyde.
• Nitrite-Testing for the presence of exogenous nitrite.
• Oxidants-Testing for the presence of oxidizing reagents.
• pH-Testing for the presence of acidic or alkaline adulterant.
• Specific Gravity-Testing for sample dilution according to apparent pKa change of certain pretreated poly electrolytes in relation to the ionic concentration.

Results are obtained by comparing the color on each of the test pads with the corresponding pad on the container color chart label.

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